The Roskamp Institute, located in Tampa, was one of few memory clinics across the United States that participated in a study that tested the effect of NSAIDs on the cognitive ability of patients suffering from Alzheimer’s disease (AD). The NSAIDs, non-steroidal anti-inflammatory drugs used to decrease inflammation, did not improve the cognitive functions of the Alzheimer’s patients. The Roskamp Institute registered over 400 seniors of at least 70 years of age. Each was required to have at least one relative with AD-like dementia. Two-third of the patients received either Naproxen or Celecoxib, and the remaining received a sugar pill. All were checked on and given memory tests annually for five years. The results showed that Naproxen may be a factor in impairing the memory and other mental functions, but further study is needed to verify if the results are consistent or if they were due to the fact that the patients who did not test as well were already suffering from early stages of dementia. The results for this study, as part of the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT), were published in Archives of Neurology.
For more information about this study, please visit http://www.ncbi.nlm.nih.gov/pubmed/18474729.
August 3, 2012