_ The early ideas dealt with the antioxidant’s and CSF biomarkers have been proved wrong. Recent studies reveal that there is no association between an antioxidant combination of vitamin E, vitamin C and α-lipoic acid (E/C/ALA) and the changes Alzheimer’s related biomarkers in the cerebrospinal fluid. Oxidative impairment is linked to aging and is common in individuals with Alzheimer's disease but the risk can be reduced by diet rich in antioxidants.